Conclusions
Multiple groups are at risk of potentially life-threatening complications due to human parvovirus B19 infection. Based on the infectious nature of HPVB19 infection in children and the severe potential consequence of transplacental fetal infection, a two-pronged vaccination strategy to manage HPVB19 infections in these populations is recommended.
First, incorporation of a HPVB19 vaccine into the early childhood vaccination schedule could reduce the overall incidence of this virus in the population. Second, a safe vaccine that can elicit protective neutralizing antibodies could be provided to women of childbearing age as prophylactic care to reduce the overall incidence of transplacental fetal infection.