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May 15, 2008 (Vol. 28, No. 10)

Optimizing the Profiling of Protein Kinases

Combining Chemistry and Instrumentation to Make the Most of microHTS and HTS Formats

  • Protein kinases comprise the largest family of mammalian enzymes, totaling at least 500. These ubiquitous enzymes play key roles in cellular regulation by catalyzing the reversible phosphorylation of more than 10,000 proteins. Dysfunctional intracellular signaling through protein kinases is associated with about 400 human diseases, most notably cancers. ...

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