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August 01, 2005 (Vol. 25, No. 14)

Optimizing Strategies for Hit-to-Lead Process

Structure-Based Libraried and Early Drug Metabolism and Phamacokinetics Studies

  • The main challenge in the process of taking a hit to a lead in drug discovery is figuring "what questions to ask and what information will best help focus lead optimization," said Simon Hirst, Ph.D., CEO of Sygnature (Nottingham, U.K.), as he introduced the Hit-to-Lead track of the "World ...

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