Thermo Fisher Scientific launched several new mass spec systems at the ASMS conference on “ Mass Spectrometry and Allied Topics” held recently in Denver. The introductions upped the ante for high-end systems, added a new benchtop system to Thermo Fisher’s product line, as well as biosoftware for advanced proteomics research.
Emerging devices, many involving advances in time-of-flight, also were discussed by Virgin Instruments, MDS Analytical Technologies, Bruker Daltonics, Photek, and many other companies.
The TSQ Vantage™ LC/MS/MS was the new system launched by Thermo Fisher at the meeting. This triple quadrupole instrument is 10 times more sensitive than any other machine of that type on the market and also boasts a 10:1 signal-to-noise ratio when compared to the TSQ Quantum series, according to Iain Mylchreest, Ph.D., vp and general manager at Thermo.
“That’s possible,” explained Dr. Mylchreest, “because of the way the new system was designed.” The TSQ Vantage system features “a new ion optical system that sprays solvent more effectively and reduces clustering by changing the physical geometries.”
Its S-Lens ion optics system uses an electrostatic field to capture “virtually every ion” and transfer it to the HyperQuad™ quadrupole mass analyzer. The advantage, said Dr. Mylchreest, is that it eliminates mass discrimination and lowers the gas load on the turbo molecular pumps, while keeping the ion optical path cleaner to maintain sensitivity. Therefore, scientists working with small molecules, biomolecules and peptides can detect compounds at ultralow quantitation levels with great precision, he added.
The optical interface also has been simplified, noted Dr. Mylchreest, removing the need for direct intervention. Although, he pointed out, users do have the option of fine-tuning the optics themselves.
Exactive™, a new benchtop LC-MS system is another “very significant launch,” said Dr. Mylchreest. This new system leverages the mass analyzer technology used in the LTQ Orbitrap™ and is designed for compound screening and identification in analytical laboratories routinely performing toxicology, environmental, and drug development workflows. It offers between-peak resolutions up to 100,000, Dr. Mylchreest said. To put that in perspective, TOF resolution typically is 10,000 to 15,000, he added. In tests, “130 points were measured with 1–2 ppm mass accuracy with only one outlier.”
Thermo Fisher Scientific also launched its “massinformatics” software at the ASMS conference. Dubbed the Proteome Discoverer, it provides a comprehensive view of quantitative and qualitative proteomic data that includes the ability to combine and compare data from multiple search engines, public databases, and dissociation methods. “It was developed to provide a more flexible platform and workflow environment,” Dr. Mylchreest explained. “The proteomics research world is moving fast,” so this software is built to be forward-compatible.