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June 15, 2012 (Vol. 32, No. 12)

New Approaches Redefine Small Molecule Discovery

  • Small molecule inhibitors (SMIs) are well-established therapeutics in the pharmaceutical industry. Some, such as Tamoxifen, an inhibitor of estrogen receptor function that is widely used in breast cancer, and flutamide, a prostate cancer therapeutic that inhibits androgen receptor signaling, are among the most successful drugs on the market. While ...

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