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March 15, 2011 (Vol. 31, No. 6)

miRNA Drugs Close In on Clinical Debut

Emerging Research Corroborates Potential for Broad Application Across Many Diseases

  • MicroRNAs (miRNAs) are master regulators involved in multiple physiological and pathological processes. These naturally occurring, noncoding, single-stranded RNAs (21–25 nucleotides long) base-pair with their target mRNA within the RISC (RNA-induced silencing complex). The latter is the same ribonucleoprotein machinery associated with siRNA-mediated gene silencing. While siRNAs are double-stranded ...

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