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February 15, 2012 (Vol. 32, No. 4)

miRNA Closes In on Therapeutic Potential

  • microRNAs (miRNAs) are short stretches—about 22 nucleotides long—of endogenously expressed noncoding RNA. They modulate gene expression by binding to complementary sequences in mRNAs, thereby preventing translation from them, possibly by causing their target mRNAs to be degraded. In metazoans, miRNAs usually bind to the 3´ untranslated region of their ...

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