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March 15, 2008 (Vol. 28, No. 6)

Metabolic Monitoring Enhances Production

Method Can Improve Success Rate of Fermentation Process Development & Transfer

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    Figure 4

    OUR and CER values can be used to fine-tune the configuration of large-scale fermentors so as to accommodate a process’ oxygen-transfer demand. While a standard stirred tank may be able to deliver between 200–250 mmol/L/h of oxygen, the actual applicable values may be lower than this value. Awareness of this limitation allows a development scientist to set boundary conditions for benchtop systems.

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