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Mar 15, 2008 (Vol. 28, No. 6)

Metabolic Monitoring Enhances Production

Method Can Improve Success Rate of Fermentation Process Development & Transfer

  • Process Scale-Up

    Solid scale-up data is required to ensure smooth scale transfer leading to first-time-right (FTR) initiation of a process to large-scale operation. A practical and easy-to-use variable is the measured OUR and CER (carbon dioxide evolution rate) that are used to follow the outcome of a process under transfer. OUR and CER are dimensionless parameters and as such, can be evaluated before and after process scale-up to judge whether or not a process has been successfully transferred (Figure 4).



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