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May 15, 2014 (Vol. 34, No. 10)

Measuring Mitochondrial Defects

XF Bioenergetic Analysis Identifies Defects in Human Skin Fibroblasts

  • Mitochondrial disorders are characterized by defective mitochondrial function in metabolically active tissues such as skeletal muscle and brain. While spectrophotometric analysis can be utilized to detect biochemical defects in muscle biopsies or skin fibroblasts, samples are difficult to obtain, require a large number of cells, and this method cannot ...

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