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Feb 15, 2009 (Vol. 29, No. 4)

Low-Volume Liquid Handling Gaining Favor

Novel Iteration Reduces Amount of Sample and Reagent Used and Speeds Processes

  • Assay Miniaturization

    Click Image To Enlarge +
    Scienion’s sciSWIFT sterile wash-free identifiable fluid technology is available in storage volumes between 30 µL (left) and 1 mL (right).

    Thermo Scientific recently launched a bulk reagent dispensing device called the Multidrop Combi. Researchers at Merck, led by Dongyu Sun, Ph.D., tested it for assay miniaturization and optimization applications and found that it demonstrated acceptable accuracy and precision at the lowest specified volume—50 nanoliters to 40 microliters—for aqueous solutions dispensing. The device is capable of dispensing liquid ranging from 0.5 to 2,500 microliters onto plates ranging from 6 to 1,536 wells with heights from 5 to 50 mm.

    Dr. Sun adds, “this platform is suitable for assay development and screening of miniaturized plate formats.”

    The Multidrop Combi is designed to save the reagent by featuring minimal dead volume and backflushing that minimizes the need for re-runs. The device can be added to a lab-automation platform for high-throughput 24/7 operations.The cassettes are autoclavable and the equipment is designed for easy cleaning For traceability, its own SMART features counts the usage of the dispensing cassette, according to Thermo Scientific.

  • Click Image To Enlarge +
    BioDot’s BioJet technology is based on the combination of a solenoid ink jet valve coupled to a positive displacement syringe.


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