Biological Assay Screening System
The VaryScreen™ system (Figure 1) was designed to carry out many of the screens that are accessible using the detection technologies supported by most multimode readers such as fluorescence adsorption, fluorescence polarization, luminescence, and UV/Visible adsorption.
The system includes a multichannel dispenser, automatic pipettor, and a microplate washer to support most liquid-handling needs. An automatic incubator and a microplate shaker nest control reaction conditions. Plates are stored and transported by a stacking system connected to the liquid handlers by a moving track. A robotic arm in the center of the system moves plates from this unit to the remaining instruments.
Samples can be prepared and read by combining the appropriate sequence of steps, as prescribed by the individual protocols. Then by applying the appropriate detection method one can carry out all sorts of assays such as FRET, TR-FRET, HTRF, LANCE, AlphaScreen™, ELISA, FP, and reporter assays including Luciferase and beta-galactosidase.