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May 15, 2010 (Vol. 30, No. 10)

iPSC-Derived Human Cardiomyocytes

Stem Cell Technology Can Facilitate Quick & Early Failure of Toxic or Ineffective NCEs

  • Summary

    Cellular Dynamics has developed a highly standardized, scalable process to manufacture human iPSC-derived cardiomyocytes. Using this process, we can produce the industrialized quantities of human cardiomyocytes needed by the pharmaceutical industry for drug toxicity testing.

    These cardiomyocytes demonstrate typical physiological properties and show appropriate sensitivity to cardiotoxic compounds expected of human cardiomyocytes. The ability to consistently produce large numbers of high-quality and high-purity cardiomyocytes offers the pharmaceutical industry a new tool to better predict the cardiotoxicity of new drug candidates.

    It is expected that these cells will allow pharmaceutical companies to more efficiently select drug candidates while reducing the likelihood that cardiotoxic activity of these compounds will manifest themselves late in development or after regulatory approval and market launch.



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