Leading the Way in Life Science Technologies

GEN Exclusives

More »

Tutorials

More »
Dec 1, 2009 (Vol. 29, No. 21)

Investigating Cell Invasion and Migration

Beyond Endpoint Analysis: Real-Time Monitoring Enables Greater Insight into Cellular Behavior

  • Conclusion

    Click Image To Enlarge +
    Figure 3. Invasion and migration kinetics of HT1080 cells in indicated dilutions of Matrigel using FBS as the chemoattractant.

    The cancerous cells shown have varying migratory and invasive behaviors, specific to chemoattractant stimuli or Matrigel concentration. The new CIM-Plate 16 for the RTCA DP instrument is a versatile device for the analysis of invasion and migration, and is the only platform capable of quantitatively measuring the invasive and migratory behavior of cells in real time without exogenous labels.

    This enables the identification of migratory and invasive time points, which will help increase throughput by shortening assay time, minimize the number of endpoint assays, and help determine optimal time points for inhibitor studies. Moreover, analysis using the xCELLigence System reduces hands-on cell manipulation steps, leading to more physiologically relevant results.



Related content

Be sure to take the GEN Poll

Cancer vs. Zika: What Worries You Most?

While Zika continues to garner a lot of news coverage, a Mayo Clinic survey reveals that Americans believe the country’s most significant healthcare challenge is cancer. Compared to other diseases, does the possibility of developing cancer worry you the most?

More »