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June 15, 2011 (Vol. 31, No. 12)

Inroads in R&D Advance Utility of miRNA

Gene Regulators Show Promise as Biomarkers and Potential Therapeutics

  • MicroRNAs—as an entirely new class of gene-expression regulators (discovered in humans in 2001)—have elicited widespread interest. These noncoding, single-stranded, 20 to 25 nucleotide RNAs regulate gene expression through sequence-specific mRNA hybridization (usually at the 3´ untranslated region) and have been shown either to block translation or steer the degradation ...

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