Already used by 11 of the world’s biggest pharmaceutical companies, the DynoChem (www.scale-up.com) platform was developed to facilitate API process development and expedite scale-up. DynoChem says the product represents a single platform for parameter fitting, simulation, and the optimization of any rate-based unit operation, for example, reaction, crystallization, evaporation, or drying.
The platform essentially uses data obtained at the lab bench in mechanistic models to expedite safe and efficient progression to pilot and commercial manufacture, explains Steve Cropper, the company’s director of sales. “In essence, DynoChem is a modelling tool that helps chemists and engineers understand the mechanics of their reactions and associated workup and isolation steps. The simulation software can predict and help circumvent process development setbacks, including the generation of reaction impurities/by-products, incompatibilities in scale-up, or yield loss and batch failure.”
For example, he continues, “an API manufacturer has shown how a modelling approach using DynoChem resulted in a reduction in the number of lots required to produce a stable process from 100 to less than 10.”
Performance Fluid Dynamics (PFD), which owns DynoChem, claims that unlike competing products, DynoChem has been developed specifically for users in the pharmaceutical, agrochemical, and specialty chemicals industries who do not have a background in modelling. The platform features over 160 predefined template models and examples for common organic synthesis reactions, work-up, and isolation steps, along with lab reactor templates. This past February the latest version, DynoChem 3.2, was released. According to the company, it delivers a new level of productivity, enabling the completion of calculations up to six times faster.