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April 01, 2010 (Vol. 30, No. 7)

Hydroxyapatite for Biomolecule Purification

With Development Pathways Determined, HA Has Become a Mainstream Industrial Staple

  • Just a decade ago, experimental work by Guerrier, Flayeux, and Boschetti demonstrated the ability of sodium chloride (NaCl) gradients on hydroxyapatite (HA) to remove aggregates from IgG preparations. This approach has since proven effective with the majority of IgG monoclonal antibodies and become the foundation of HA’s growing popularity. ...

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