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January 01, 2014 (Vol. 34, No. 1)

High-Sensitivity Detection of Cancer Biomarkers

Somatic Mutation PCR Testing Suppresses Amplification of Wild-Type Template DNA, Selectively Amplifies Mutant Templates

  • In the context of personalized cancer treatment, the “gold standard” for tumor mutational analysis is DNA sequencing. This approach, however, is not entirely satisfactory. Recent studies indicate that it is one of the least sensitive methods for characterizing mutation. In fact, with DNA sequencing, a mutation must be present ...

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