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July 01, 2011 (Vol. 31, No. 13)

Harnessing Nuclear Receptors

Therapeutics in Development Aim to Enhance Selectivity and Reduce Potential Side Effects

  • Nuclear receptors drive many critical processes ranging from metabolism to reproduction by serving as ligand-activated transcription factors. They also represent a lucrative area for drug discovery as evidenced by current therapies utilizing glucocorticoids for asthma, estrogens for hormone-replacement therapy, and retinoids for acne. Current efforts continue to take ...

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