Solvent Selection Guide
ACS GCIPR introduced its solvent selection guide recently, based upon safety, health, and environmental parameters. “Because effectiveness of a solvent for a particular reaction or work-up step depends upon the chemistry and conditions used, the effectiveness of the solvent was not included in the scope of this work,” Hargreaves said.
The PDF version of the guide is available at www.acs.org/gcipharmaroundtable, and as an iPhone app. The guide may be used to “compare solvents scored in the Roundtable guide to those of their own corporate guides, and to raise awareness and provide a resource.”
“By switching to green solvents, a company can expect equivalent functional and performance with minimized environmental impact.”
Green chemistry also may lower waste disposal costs for harmful solvents, reduce the need for expensive emissions abatement equipment, and lower the costs of virgin solvent when solvents can be recycled. Other speakers added greater efficiency and reduced energy use to green chemistry’s attributes.
But, there are tradeoffs, Hargreaves acknowledged. “Some newer alternatives may still be limited in production scale and the number of available suppliers, and some common laboratory reagents may not be readily available in the new alternative solvents.”
Additionally, there are data gaps for some green solutions, making it difficult to fully assess them against the Roundtable solvent selection guide. “Regulatory guidance is not yet in place for some of the newer alternatives,” she added.