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May 01, 2008 (Vol. 28, No. 9)

GPCRs Remain “Hot” Drug Targets

A Flurry of Activity in the Field Has Resulted in New Methodologies that Increase Leads

  • GPCRs represent the largest family of genes expressed in the human genome, according to Jeremy Richman, Ph.D., associate director, cardiovascular biology, at Arena Pharmaceuticals . “Their cell membrane localization, the diversity of tissue expression, and the fact that they have the potential to elicit essentially every signaling pathway, makes these ...

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