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April 15, 2014 (Vol. 34, No. 8)

GPCR Insights Brighten Drug Discovery Outlook

  • Recent years have seen major advances in understanding the structure-function relationships of G protein-coupled receptors (GPCRs). This large superfamily of transmembrane receptors comprises over 800 members in humans. GPCRs regulate a wide variety of physiological processes including sensation (vision, taste, and smell), growth, hormone responses, and regulation of ...

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