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Mar 1, 2011 (Vol. 31, No. 5)

Getting Up to Speed with Modern LC-MS

More Sophisticated Instruments Streamline Practices but Introduce New Challenges in the Process

  • Qual-Quant

    Click Image To Enlarge +
    The AB Sciex TripleTOF™ 5600 System integrates qualitative exploration, rapid profiling, and high-resolution quantitation workflows on a single platform, the company reports.

    Traditionally, scientists have had to choose between the high resolution and selectivity of an accurate mass instrument used for qualitative mass spectrometry, and the sensitivity, dynamic range, and speed of a nominal mass instrument preferred for quantitative work.

    The AB Sciex  TripleTOF™ 5600 offers the best of both worlds with no need to compromise, according to Gary Impey, the company’s director of pharma and CRO business. “Because of the speed and sensitivity, along with high-resolution accurate mass capabilities, the instrument can do the qualitative workflows quite easily, but additionally does triple quadrupole-like quantitation as well.”

    “Within a single analysis you could be doing high-throughput relative quant on the parent drug, while at the same time getting identification of the major metabolites.”

    To accomplish this, AB Sciex started with “the front end of our 5500 platform—the QTrap 5500, which provided enhanced sensitivity.” The ToF Analyzer™ was added to the mix, “to deliver the high resolution at the speed and sensitivity required for high-end triple quad-like quantitation,” he explains. To top it off, a 40 GHz multichannel TCD detector provides the highest sampling speeds and maintains high resolution, even at low mass. “This is about ten times faster than any other detector on the market today,” extols Impey.

  • Equipment Grant Program for LC-MS Research

    PerkinElmer says it will award up to $1,000,000 worth of equipment grants during 2011 to scientists pursuing improvements to environmental and human health. The company expects to work closely with the researchers over the life of the program beyond the initial awarding of funds. This grant opportunity will be focused on researchers that require the use of liquid chromatography mass spectrometry.

    To learn more about the program and to submit an application and abstract online, please go to

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