DELIVERING CELLS INTRANASALLY TO THE BRAIN
William Frey, Ph.D., codirector, Alzheimer’s Research Center, Regions Hospital, St. Paul, MN, and professor, oral biology and pharmaceutics, University of Minnesota.
GEN Podcast, July 16, 2009.
For decades the blood-brain barrier has served as the major obstacle to the use of many therapeutic agents for central nervous system disorders. However, a noninvasive, intranasal method of bypassing the blood-brain barrier to deliver drugs to the brain and spinal cord was revealed by Dr. Frey in 1992.
Now Dr. Frey and collaborators in Germany report that stem cells can be noninvasively delivered to the brain using the intranasal method. They accomplished this goal in an animal model and noted that they bypassed the blood-brain barrier.