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May 01, 2006 (Vol. 26, No. 9)

Fragment-Based Drug Design Optimizes Hits

Find More Patentable Compounds with Fewer Screens Using Protein Crystallography

  • Fragment-based drug design is a new approach that has been successfully applied to challenging targets, such as protein-protein interactions. While 3-D protein structures have been used in drug discovery for many years now, fragment-based drug design uses x-ray crystallography or other physical techniques to screen fragment libraries for specific ...

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