X-Man cell lines are a powerful tool to predict patient responses to targeted therapies and they provide a definitive understanding of the genetic factors that mediate their sensitivity or resistance to such agents. Further in vitro studies are now ongoing using a suite of SW48 based X-Man cell lines covering several other variations of mutant K-Ras and other genotypes for their effects on EGFR-targeted agents.
Other targeted agents are also being tested in this system so as to potentially inform the prospective integration of clinical biomarkers into new clinical trials. Expanding on this ambition, Horizon and several translational and clinical collaborators have been awarded a large consortium grant to define and integrate new genetic biomarkers into X-Man models and build algorithm for prospective clinical trials.
Genetically defined X-Man human cell lines are important tools to predict which patients will benefit from new targeted or personalized medicines. Building upon the K-Ras/Erbitux data, examples of personalized medicine will become increasingly manifold as such models are extended upon and increasingly disseminated within the academic and industrial research community.