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January 01, 2005 (Vol. 25, No. 1)

Exploiting Post-Translational Modifications

Assessing Strategies to Meet Demand

  • By 2010, glycoprotein and antibody drugs are expected to exceed $68 billion in worldwide sales. Meeting the demand for such therapeutics is generating challenges for both production and manufacturing. Chief among these is accurately and reproducibly mimicking natural post-translational modifications. Identifying and characterizing such modifications impact half-life, quality, ...

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