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April 01, 2007 (Vol. 27, No. 7)

Designing Out Up-& Downstream Mismatches

Thoughtful Planning Equals Efficiency, While Built-in Flexibility Leaves Wiggle Room

  • Discrepancies between the material output of cell culture and fermentation and the capacity of downstream purification has long been a point of debate in biotechnology. The bad news, if one can call it so, is that protein titers are rising, even for established processes. The good news is that ...

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