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July 01, 2007 (Vol. 27, No. 13)

Designing Better Purification Schemes

Overcoming the Impracticalities of Downstream Single-use Systems

  • Efforts to raise protein-expression levels have succeeded mightily, but at a cost. Today, high protein titers and accompanying impurity levels have come to dominate downstream processing. “We have undergone a shift in where bottlenecks occur, from cell culture to purification,” says Jonathan Romero, Ph.D., a senior development engineer ...

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