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April 15, 2007 (Vol. 27, No. 8)

Companies Step Up to GPCR Challenge

New Technologies and Approaches Facilitate the Discovery of Ligands

  • G protein-coupled receptors (GPCRs) are transmembrane proteins that transduce an extracellular signal—ligand binding—into an intracellular signal—activation of G-protein—which in turn activates various key cellular pathways. GPCRs represent the largest protein family in the human genome and play a vital role in many biochemical and physiological processes, from cell-to-cell communication ...

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