ChemDiv has established business connections with more than 400 major pharmaceutical and biotechnology companies and worldclass research institutes worldwide, including Merck, Sanofi-Aventis, Schering, Novo Nordisk, Genentech, and Johns Hopkins and Stanford Universities, among others. In one of the latest collaborations launched in March, ChemDiv and Berlex, a U.S. affiliate of Schering, will work to discover new lead compounds against several GPCR targets associated with several disease areas.
Two years ago, Euroscreen teamed up with ChemDiv to develop drug candidates against chemokine receptors, a specific type of GPCR target associated with inflammation, immune disorders, and cancer. Euroscreen is building a patent portfolio of GPCR targets and novel drug leads to license to biopharmaceutical companies. The patents include GPCR receptors involved in metabolic defects, obesity, and diabetes.
The National Institute of Diabetes, Digestive and Kidney Diseases awarded AdipoGenix and ChemDiv an SBIR grant to find small molecules that target human fat tissue as a therapy for obesity and type 2 diabetes. ChemDiv supplies AdipoGenix with specific small molecule libraries and custom chemistry services to support AdipoGenix’ biology platform, which screens for compounds that reduce fat in human cells and identifies the mechanism of action and molecular targets.
Inappropriate activation of the Hedgehog pathway is associated with a variety of tumors, including basal cell carcinoma, medulloblastoma, and pancreatic cancer. In collaboration with researchers at Stanford University, ChemDiv is designing compound libraries for screening the Hedgehog pathway. To identify new druggable targets, ChemDiv is focusing on the discovery of mechanistically distinct antagonists using a NIH-3T3 cell-based assay.
The University of Maryland Greenebaum Cancer Center in Baltimore partnered with ChemDiv to discover treatments for breast cancer. ChemDiv provides access to its diverse screening libraries, medicinal chemistry services, and computational chemistry technologies to improve the chances of finding high-affinity compounds that selectively target breast cancer cells with defined genetic alterations.
The anticancer drugs Gleevec, Iressa, and Tarceva all inhibit protein kinases, yet the development of protein kinase inhibitors for the treatment of cancer is still in its infancy. ProQinase and ChemDiv are searching for new kinase inhibitors by combining ProQinase’s state-of-the-art molecular biology and screening platforms with ChemDiv’s discovery biology platform. Both companies will share development costs and revenues to develop novel kinase inhibitors into anticancer therapies.