Ferruccio Messi, Ph.D., founder of Cell Culture Technologies, has developed minimal culture environments that streamline the purification process for cell-culture based products. “They are protein- and peptide-free and consist of a mixture of water and molecules only,” he says, which simplifies purification.
A complex culture medium is, by its very nature, an undefined nutrient mixture, Dr. Messi stresses. “You can’t control your culture process if you don’t know what’s around the cell. Cells continuously interact with their environment, and if you don’t know what’s in that environment, there’s no way to accurately predict how cell metabolism will be affected.
“With our technology, we eliminate that problem.” Cell Culture Technologies’ minimal culture media are made exclusively of tissue culture, water and chemically defined small molecules. Consequently, users can develop a methodology that governs cell behavior, based upon understanding and maintaining the nutritional balance of the culture media.
“There’s also an advantage in upstream development by knowing what chemicals surround the cell.” That results in better control, which produces a more consistent outcome, lower costs, and speeds purification. “Product can be harvested in almost a purified form.”