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April 15, 2009 (Vol. 29, No. 8)

Capitalizing on Fragment-Based Discovery

Computational and Medicinal Chemists Are Joining Forces to Turn Hits into Leads

  • Fragment-based drug discovery is gaining momentum as an efficient strategy to find and optimize leads. The technology first identifies small chemical fragments that bind weakly, yet efficiently, to the target, and then grows or combines them to produce a lead with a higher affinity. Fragment-based discovery differs from ...

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