The amorfrutins are an example of promising natural compounds stored in AnalytiCon’s MEGx library and semi-synthetic compounds in the NATx library. These libraries are continuously expanded and include more than 28,000 compounds based on 2,000 chemotypes. The structures of all compounds are completely resolved, and they are ready to be screened.
The MEGx library comprises 1,200 natural products purified from microbial strains (terrestrial and marine sources) and 3,600 natural products purified from plants. Among the microbial products, 70% are novel, as are 40% of plant products. The identity of each natural product is confirmed by LC/MS and NMR. The collection contains highly diverse small molecules, many of which have not been previously published. A proprietary fermentation, profiling, isolation, and structure elucidation process (MEGAbolite®) insures a reliable supply of a natural product for scale up.
The NATx library contains 23,000 compounds with unique three-dimensional chiral scaffolds and decorated pharmacophore functionalities. They combine the advantages of highly evolved natural products with parallel chemistry for efficient drug discovery, such as hit-to-lead optimization. Unique 3D fragments with established chemistry are also available for fragment-based drug discovery.
AnalytiCon Discovery also has a huge collection of plants and microbial strains in storage. “We’re always looking for new biomaterials, and we continuously enhance our collection,” says Dr. Wolf. Biomaterials are collected worldwide under contracts with local governments and authorized organizations, and rules governing biodiversity are always respected.
AnalytiCon’s staff includes natural product and medicinal chemists, biochemists, biologists, and pharmacologists who support clients to develop active ingredients and products. Customers include no less than 75 international companies working in the pharmaceutical, food, and cosmetics industries.
Customers can benefit from a variety of related services, such as structural elucidation, biological screening, assay development, biochemistry support services, and total synthesis of natural products. Assay development routinely involves optimization and validation of critical pathways that drive med-chem programs and lead decisions. Biochemical expertise covers the isolation, characterization, and identification of native proteins from mammalian cells, tissues, and organs for target/biomarker discovery.
For lead generation, the company offers target-to-lead drug discovery modules based on tailored biology and pharmacology building blocks. Clients can select, modify, and align these tools in individual ways.