Stepmag Scale-up Systems, introduced last March by Sepmag, perform isolations in multiple tubes of varying sizes simultaneously. Bryan Rittenberry, responsible for Sepmag U.S. operations, says this technology is based on a circular magnetic system that creates homogeneous separation conditions, so the vast majority of beads experience the same magnetic force. “There are no stray magnetic fields, and up to 99 percent of the beads are recovered from the tubes.”
Tubes of 1.5 mL, 10 mL, and 50 mL can be placed in one holder within the ring for simultaneous separations, or 250 mL separations can be performed using the entire ring. “The Stepmag is a small version of a larger system, designed for R&D work.” Scale-up to 30 liter batches can be performed on the same family of machines using the same technology.
Dexter Magnetic Technologies develops custom separations equipment and custom configurations of existing equipment for its customers. According to Doug Hartl, business manager, medical and LifeSep products, customers are interested in varying magnet placement and strength for its standard plate separators and bundling fixed-well plates with varying magnetics for high-throughput separations.