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December 01, 2012 (Vol. 32, No. 21)

Better, Earlier ADME/Tox Predictions in Cells

  • Whole-animal models are still the gold standard for toxicity predictions and are required by regulatory agencies, yet for many biological pathways and mechanisms they do not provide a good extrapolation to humans. In vitro surrogate assays provide more representative methods to rule out adverse effects early in the ...

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