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April 01, 2014 (Vol. 34, No. 7)

Are Capacity Mismatches a Real Problem?

  • Since bioprocesses consist of discrete, successive unit operations, relatively slow steps could cause holdups or bottlenecks. This fact, in light of upstream efficiency improvements, has given rise to the notion of “capacity mismatch” between cell culture and purification—the consequence, if you will, of too much of a good thing. ...

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