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August 01, 2007 (Vol. 27, No. 14)

Application Note: Internalization and Protein Relocation

Selective Labeling Approach Can Reduce Intracellular Background

  • G protein-coupled receptors (GPCR) are a large and diverse class of plasma membrane receptors involved in transduction of extracellular signals. The range of GPCR ligands is broad and includes small biogenic amines and peptides (e.g. cytokines) that bind to the extracellular domains of GPCRs to activate various signaling pathways. ...

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