The measurement of cell respiratory control is the single most useful test of mitochondrial (dys)function in cells, as reported by renowned bioenergetic scientists Martin Brand, Ph.D., (Buck Institute for Research on Aging, Novato, CA), and David Nicholls, Ph.D., (MRC Mitochondrial Biology Unit, U.K.), in the March 2011 Journal of Biochemistry.
Launched in 2006, the award-winning XF Extracellular Flux Analyzer is the industry standard for measuring cellular bioenergetics, simultaneously measuring the two major energy-producing pathways of the cell—mitochondrial respiration and glycolysis—in a microplate, in real-time.
The XF Analyzer and associated kits determine in vitro oxygen consumption, glycolysis, mitochondrial (dys)function, and fatty acid oxidation. Any cell type can be assayed on the XF Analyzer, including primary, adherent, and suspension cells, as well as islets and isolated mitochondria.
Over 1,500 life sciences researchers worldwide are using the XF Analyzer to further their research into mitochondrial (dys)function, and their collaborative knowledge has been incorporated into the XF Cell Mito Stress Test Kit, which provides a complete cellular bioenergetic profile, by measuring the key parameters of mitochondrial (dys)function, and revealing critical information earlier, information not available in basal metabolism alone.
The XF Cell Mito Stress Test Kit has simplified cellular bioenergetic studies and has become the worldwide standard for measuring mitochondrial (dys)function.