Previously available detection methods for quantifying low-abundance biomarkers, such as IL-17A, IL-17F, and IL-17AF were inadequate due to lower limits of quantification.
The patented single-molecule counting technology provided by Singulex offers superior sensitivity over traditional immunoassays. With high precision and sub-picogram per mL lower limits of quantification, only a minute sample volume is required for the determination of biomarker concentration at baseline levels. This allows precious sample to be conserved from high-profile clinical study specimens, and multipanel studies to be performed.
Singulex solutions provide high-resolution monitoring of baseline IL-17A concentrations that are present at low levels, allowing for a clear differentiation of the disease state from the healthy population. The technology also enabled quantification of other IL-17 isoforms in RA patients, which have not been well characterized before.