Nuclear receptors play a key role in pharmaceuticals, nutrition, and toxicology. They are targets for diseases such as cancer, diabetes, obesity, heart disease and cholesterol transport. They also impact drug metabolism and pharmacokinetics as well as drug-drug interactions.
The key markets for Indigo’s products and services include the biopharmaceutical sector, CROs, chemical companies, nutritional companies, and academic and government researchers. Basically, anyone seeking to better understand how a xenobiotic—a drug, food additive, chemical or pollutant—impacts the human body can use Indigo assays or services.
Researchers in the biopharmaceutical space choose Indigo kits and services for screening compounds for both on-target and off-target or toxicology screens. The convenient ready-to use kits are automation friendly, allowing them to easily integrate into an HTS campaign for drug discovery and lead identification. The ease of use allows for quick, multiple assays during lead optimization, and the large variety of kits and services makes off-target profiling and discovery toxicology screening simple.
With the widest variety of nuclear receptor kits and services available, researchers will find quick answers to their questions. The availability of common orthologs such as rat and mouse allows chemical and pharmaceutical companies to validate animal models, and nutritional companies can check for activity against an array of genes or nuclear receptor targets.