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September 01, 2007 (Vol. 27, No. 15)

Advancing Most Promising Compounds

Determining Safety, Efficacy, and Toxicity Earlier Is the Next Big Challenge

  • In medicinal chemistry, getting a read on toxicity earlier on in the drug discovery process is critical, said Jefferson Tilley, senior director, discovery chemistry at Hoffmann-LaRoche (www.rocheusa.com). “Toxicity is an issue, consequently there is a high attrition rate.” “It takes 12 to 15 years and billions of research ...

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