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GEN Podcast: Magnetically Driven Nanoparticle Gene Delivery

Thursday, November 08, 2007

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After binding DNA segments to iron-containing nanoparticles, scientists have used magnetic fields to direct the nanoparticles into arterial muscle cells, where the DNA could have a therapeutic effect. Although the research, done in cell cultures, is in early stages, it may represent a new method for delivering gene therapy to benefit blood vessels damaged by arterial disease.

During this week's GEN podcast, Dr. Robert Levy, the study leader from the Children's Hospital of Philadelphia, talks about the promise of nanoparticles for gene delivery and the benefit of applying a magnetic field to a nanoparticle gene delivery application. Noting that other scientists had previously shown that magnetically driven nanoparticles could deliver DNA in cell culture, he discusses the novel advantages of his specific system for gene delivery as well as why the DNA was placed on the surface of the nanoparticles instead of inside them.

While Dr. Levy's work focused on delivering genes to muscle tissue in cell culture, he suggests some additional applications for the technology. Dr. Levy also provides details on further planned studies involving his group's nanoparticle gene delivery technique?

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What do you think are some other gene delivery applications for the use of magnetically driven nanoparticles?

Or, if you prefer, post your own topic on the biotech industry subject of your choice. Please share your opinions and observations.

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