Cardio3 BioSciences is a biopharmaceutical company involved in the discovery, development, and commercialization of regenerative and protective therapies for cardiovascular diseases.The aim of these therapies is to protect the heart during myocardial injury, reduce the volume of the scar and reconstruct damaged heart tissue. The company’s product candidates and research programs are based on the proprietary Cardiopoiesis technology platform, which is based on fundamental research conducted at Mayo Clinic.

Catabasis is a clinical stage company that develops products to target inflammatory, immunological and metabolic diseases. It's SMART linker platform technology produces new chemical entities that have amplified efficacy along a clinically validated disease pathway through the conjugation of two known products via a linker that is metabolized intracellularly in cells relevant to the particular disease.

Cellworks has built a pipeline of drug candidates for cancer and rheumatoid arthritis by implementing a novel approach to therapeutic design and development. The Cellworks approach combines a predictive and responsive network of protein interactions with sophisticated algorithms to emulate human physiology and predict clinical outcomes early on. The company is using this technology to design novel mechanism of actions by combining existing FDA approved drugs that work synergistically to impact multiple disease pathways simultaneously. 

Cleave Biosciences is discovering and developing novel small molecule therapies for difficult-to-treat cancers by targeting protein homeostasis through the ubiquitin proteasome and autophagy systems, an area of unrealized potential. Cleave is using molecular profiling approaches with the goal of identifying patient subsets most likely to benefit from each of its targeted drugs.

Curiox Biosystems develops and commercializes cellular assay systems. Its first product, the DropArray™ platform, is intended to accelerate the progress of basic research, drug discovery and diagnostics through the miniaturization and automation of bioassays. The Curiox DropArray platform allows scientists to perform low-volume cellular assays efficiently using adherent, weakly adherent and even non-adherent cells, achieving long-term on-plate incubations without evaporation. Curiox recently introduced the LT210 (low throughput) or HT200 (high throughput) DropArray Washing Stations to automate the task of adding or changing media and buffers.

CytomX is a biotechnology company focused on improving the monoclonal antibody field by creating a new generation of highly targeted antibody therapeutics. CytomX's Probody™ Platform represents a transformational drug discovery and development approach for antibodies, enabling improved specificity, increased efficacy and decreased toxicity. 

Dezima Pharma develops drugs to treat dyslipidemia, a major modifiable risk for cardiovascular disease. Its objective is to develop compounds from pre-clinical development to meaningful proof of concept in patients. Dezima will seek strategic partners to further development in the larger cardiovascular indications, and/or continue in-house development of its compounds in smaller, orphan-type indications. The Netherlands-based company was founded by Forbion Capital Partner and BioGeneration Ventures.

Dynamic Biosensors develops and commercializes the proprietary switchSENSE technology for molecular interaction analysis. In addition to binding affinity and kinetics, the dynamic character switchSENSE allows to determine molecular size, conformational changes, charge, and certain post-translational modifications of the target in the same measurement. Dynamic Biosensors is a spin-off of the Technische Universität München.

eADMET is an expert in the creation of customized computational models for the prediction of important ADME/Tox properties of small drug-like molecules. The company’s modular approach combines proprietary and selected external algorithms to inform the creation of customized prediction models (with integrated error estimation) for clients and partners from the pharmaceutical and biotechnology industry.

Elcelyx Therapeutics is a privately-held company developing products for weight management and obesity-related metabolic disorders based on the science of nutrient sensing. Elcelyx product candidates, Lovidia™ and NewMet™, are Gut Sensory Modulators backed by research and clinical data demonstrating their ability to rapidly reduce weight and improve glucose metabolism without systemic side effects, respectively.