In the June issue of the journal Cell Stem Cell, a team of scientists reported success in what may be the first documented rescue of a congenital brain disorder by transplantation of human neural stem cells. The researchers developed a new transplant procedure that resulted in infiltration of human glial progenitor cells throughout the brain and spinal cord of shiverer mice. The engrafted mice exhibited robust, efficient, and functional myelination, according to the scientists.
During this week's GEN podcast, research team member Dr. Steven Goldman, from the University of Rochester Medical Center, discusses the purpose of the experiment and the final results. He also explains how his team's studies differ from other research that focuses on remylineating nerve cells. Regarding the group's novel cell delivery strategy, Dr. Goldman describes the approach in detail as well as its advantages over other cell delivery methods.