BioPerspectives

Apr 17, 2008

miRNAs and Cancer

  • The association between miRNAs and cancer has become one of the most intense areas of interest in biomedicine. Key goals are to help determine the prognosis of a cancer patient once diagnosed and develop the most promising course of therapy.

    During this week's GEN podcast, Dr. George Calin from M. D. Anderson provides additional details on why work on miRNAs has become such a hotbed of research activity in the life sciences. He notes the evidence of a significant role for miRNAs in cancer and discusses what he and his team call the main paradigms for the involvement of miRNAs in human cancers.

    Dr. Calin also talks about the importance of genome-wide profiling in miRNA research and offers examples of how miRNA arrays and quantitative RT-PCR technologies are used in such genome-wide profiling studies. In addition, he explains the theoretical rationale for using miRNAs in cancer treatment.