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Apr 01, 2008 (Vol. 28, No. 7)

The RNA Modification Database

URL:library.med.utah.edu/RNAmods/trnabase/
  • Nice collection of RNA info
  • Not tightly organized
RNAs are much more interesting molecules than DNA. Consider their multiple forms, the fact that they can act as catalysts of chemical reactions, and that they are often extensively modified chemically. That last property of these nucleic acids is the focus of this interesting collection, maintained at the University of Utah, though it was not apparent by whom. The diversity of modification is amazing – over 90 different nucleoside modifications. These include modifications in the all the major forms of RNA, including tRNA, rRNA, mRNA, tmRNA, snRNA, and even chromosomal RNAs. Organisms containing the modifications include representatives of archaea, eubacteria, and eukaryotes. The site’s approach to covering these modifications is a bit unsatisfying, with information loosely organized via links in a panel on the left side of the page and through a search function link at the top of the page. Results returned from the search engine showed structures, formulas, names, phylogenetic sources, and references. Clearly useful for researchers, the site could do more to be of general interest to others.
  • Key:
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*The opinions expressed are solely those of the author(s) and should not be construed as reflecting the viewpoints of the publisher, Genetic Engineering & Biotechnology News, Mary Ann Liebert, Inc., the publishing house, or employees and affiliates thereof.

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