Humanizing Animals for Immuno-Oncology
Success in Humanizing Mice Has Inspired Similar Efforts in Rats, Pigs, and Other Animals
Molecular Dx Has Your (Copy) Number
CNV Detection and Analysis Tools Are Being Used To Fill Genetic Diagnostic Gaps
Transcript-Savvy Discovery Is a Smart Bet
Drug Developers Are Finding Ways to Bend the Transcriptome to Their Will
10 Takeover Targets of 2016
Which Biopharmas Do Wall Street Watchers View As Top Buyout Candidates?
Protein Ligand Database
It’s the touching story of when protein meets ligand: bonded by hydrogen bonds and hydrophobic contacts, the pair can go on to regulate gene expression, facilitate cell signaling, or mediate metabolism. The Protein Ligand Database (or PLD, as insiders in the business like to call it), developed at the University of Cambridge, is a nice database for researchers interested in studying the nature of protein-ligand interactions. Currently containing 485 protein-ligand complexes, the database continues to be expanded. One can search by protein name or function, ligand name or origin (natural product versus xenobiotic), or by interaction type. There are also tools available to view experimental and predicted binding energies. With a simple design, the website is easy to navigate. This is a good resource for researchers that will continue to improve as the database expands.