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Just as insurance companies boast that they allow shoppers to compare multiple competitors’ rates simultaneously, Melina II is a one-stop online resource for researchers looking to identify potential DNA binding motifs within their sequences of interest. With Melina II, users can analyze their input sequence with up to four promoter analysis programs simultaneously. The five programs from which to choose are: Consensus, MEME, Gibbs sampler, MDscan, and Weeder. Results are displayed in an easy-to-interpret manner, including an alignment that compares the results from each prediction program. In addition to customizable search parameters, Melina II is also equipped with options to either search for the identified consensus sequences in the genome of human, mouse, B. subtilis, or E. coli, or to compare the identified sequence against known transcription factor binding sites.