Leading the Way in Life Science Technologies

GEN Exclusives

More »

Best of the Web

More »
Jul 01, 2007 (Vol. 27, No. 13)

FHD.van Batenburg: Homepage of PseudoBase

  • Useful research database
  • Narrow focus
Pseudoknots are RNA structures that only a molecular biologist could get excited about. Known for over 20 years, pseudoknots are unusual secondary/tertiary structures of RNA molecules that resemble a knot and are more complicated than the basic secondary structures often shown for rRNAs or tRNAs. What, you may wonder, are the purposes or use of pseudoknots? A fair question, but not one for which the answer is fully known nor one about which I am conversant. That perhaps is a subject for another site. The purpose of this site is not answering questions of purpose but rather to allow users to retrieve sequences recognized in the literature as pseudoknots. As noted on the pages, collecting pseudoknot info is not a simple exercise, as these are often footnotes of papers and more importantly, not everyone agrees on whether given RNAs form such structures. Accordingly, notes are provided with the purported knots as “supported by” to identify who proposed the structure.
  • Key:
  • Strong Points
  • Weak Points
  • Ratings:
  • Excellent
  • Very Good
  • Good

*The opinions expressed are solely those of the author(s) and should not be construed as reflecting the viewpoints of the publisher, Genetic Engineering & Biotechnology News, Mary Ann Liebert, Inc., the publishing house, or employees and affiliates thereof.

Be sure to take the GEN Poll

Scientifically Studying Ecstasy

MDMA (commonly known as the empathogen “ecstasy”) is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.

Do you agree that ecstasy should be studied for its potential therapeutic benefits?

More »